Sensing core histone phosphorylation — A matter of perfect timing

Histone core phosphorylation regulates DNA accessibility 1 Histone Core Phosphorylation Regulates DNA Accessibility

Nucleosome unwrapping dynamics provide transient access to the complexes involved in DNA transcription, repair and replication, while regulation of nucleosome unwrapping modulates occupancy of these complexes. Histone H3 is phosphorylated at Tyrosine 41 (H3Y41ph) and Threonine 45 (H3T45ph). H3Y41ph is implicated in regulating transcription, while H3T45ph is involved in DNA replication and apopt...

perfect timing of tracheostomy in patients with traumatic brain injury

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News feature: A matter of timing.

Emotional automaticity is a matter of timing.

There has been a long controversy concerning whether the amygdala's response to emotional stimuli is automatic or dependent on attentional load. Using magnoencephalography and an advanced beamformer source localization technique, we found that amygdala automaticity was a function of time: while early amygdala responding to emotional stimuli (40-140 ms) was unaffected by attentional load, later ...

A matter of timing and precision

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